NA-MIC Project Weeks

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Establishing Feature Correspondences between ultrasound images acquired at different time points during brain tumor resection

Key Investigators

• Nick Jowkar (Brigham and Women’s Hospital)
• Clement Mirabel (Brigham and Women’s Hospital)
• Sarah Frisken (Brigham and Women’s Hospital)
• Tina Kapur (Brigham and Women’s Hospital)

Project Description

The overarching goal of this project is to use pre- and intra-operative imaging to help neurosurgeons determine whether gross total resection has been achieved.

Objective

1. Objective A. Manually identify 10-15 corresponding features in ultrasound images from 5 patients. Save results.
2. Objective B. Review these landmarks with available neurosurgical ultrasound experts at project week

Approach and Plan

1. We will identify corresponding landmarks or features in 3D ultrasound images acquired during different time points in brain tumor resection.
2. We are using 3D Slicer to visualize, explore, and annotate these landmarks in ultrasound images.

Progress and Next Steps

1. Annotated intra-operative ultrasound for 4 patients.
2. Next step - measure intra-operator and inter-operator variability in these landmarks

Illustrations

1. Picture of the fiducial on the T2 pre-operative MRI image located on a sulcus
2. Picture of the pre-dura Ultrasound scan on top of the MRI scan showing the same fiducial on the sulcus
3. Screenshot of the pre-dura ultrasound with the fiducial on the sulcus
4. Screenshot of the post-dura ultrasound fiducial located on the sulcus
5. Screenshot of the pre-iMRI of the fiducial located on the sulcus

Background and References